Structure of PDB 8h1t Chain D Binding Site BS02

Receptor Information
>8h1t Chain D (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRL
AHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSS
Ligand information
>8h1t Chain J (length=167) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccggcactggaacaggatgtatatatgtgacacgtgcctggagactaggg
agtaatccccttggcggttaaaacgcgggggacagcgcgtacgtgcgttt
aagcggtgctagagctgtctacgaccaattgagcggcctcggcaccggga
ttctccaggggatccgg
Receptor-Ligand Complex Structure
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PDB8h1t Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		S32 Y42 I54 S55 S56 R86 S87 T88
Binding residue
(residue number reindexed from 1)		S2 Y12 I24 S25 S26 R56 S57 T58
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006334 nucleosome assembly
GO:0019731 antibacterial humoral response
GO:0042742 defense response to bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h1t, PDBe:8h1t, PDBj:8h1t
PDBsum8h1t
PubMed36991118
UniProtQ16778|H2B2E_HUMAN Histone H2B type 2-E (Gene Name=H2BC21)

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