Structure of PDB 8fw5 Chain D Binding Site BS02

Receptor Information
>8fw5 Chain D (length=301) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRKKVLLMGRSGSGKSSMRSIVFSNYVAKDTRRLGATIDIEHSHVRFLGN
LVLNLWDCGGQEAFMENYLSAQRDHIFRNVQVLIYVFDVESREFERDLVT
FRNCLEATVANSPQARVFCLIHKMDLVQEDLRDLVFEERKAILLETSKDL
ETTCLATSIWDETLFKAWSAIVYTLIPNTPTLESHLREFAKAAEAAEVIL
FERTTFLVISSYSSESNPATDAHRFEKISNIVKQFKLSCSKMQAQFTTFE
LRGGNFSAFIVPYTEDTYILVVIADPEIESAVTLMNIQSARRFIEASKSA
S
Ligand information
Ligand IDAF3
InChIInChI=1S/Al.3FH/h;3*1H/q+3;;;/p-3
InChIKeyKLZUFWVZNOTSEM-UHFFFAOYSA-K
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al](F)F
FormulaAl F3
NameALUMINUM FLUORIDE
ChEMBL
DrugBank
ZINC
PDB chain8fw5 Chain D Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fw5 Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing.
Resolution3.08 Å
Binding residue
(original residue number in PDB)		K15 T37 G60 Q61
Binding residue
(residue number reindexed from 1)		K15 T37 G60 Q61
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0009267 cellular response to starvation
GO:0010507 negative regulation of autophagy
GO:0110045 negative regulation of cell cycle switching, mitotic to meiotic cell cycle
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:1990131 Gtr1-Gtr2 GTPase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fw5, PDBe:8fw5, PDBj:8fw5
PDBsum8fw5
PubMed37453417
UniProtO74824|RAGAB_SCHPO GTP-binding protein gtr1 (Gene Name=gtr1)

[Back to BioLiP]