Structure of PDB 8faz Chain D Binding Site BS02

Receptor Information
>8faz Chain D (length=303) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALV
ALRRVLLAQFSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGE
VTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQ
AKTQDEEEQAEALRRIQVVHAFDIFQMLDVLQELRGTVAQQSGTVKVVVV
DSVTAVVSPLLGGQQREGLALMMQLARELKTLARDLGMAVVVTNHITRDR
DSGRLKPALGRSWSFVPSTRILLDTIGGRRMACLAKSSRQPTGFQEMVDI
GTW
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8faz Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8faz Structural insights into BCDX2 complex function in homologous recombination.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		T114 D206
Binding residue
(residue number reindexed from 1)		T113 D201
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity
GO:0043015 gamma-tubulin binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
GO:0007131 reciprocal meiotic recombination
GO:0036297 interstrand cross-link repair
GO:0042148 DNA strand invasion
GO:0051276 chromosome organization
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8faz, PDBe:8faz, PDBj:8faz
PDBsum8faz
PubMed37344589
UniProtO75771|RA51D_HUMAN DNA repair protein RAD51 homolog 4 (Gene Name=RAD51D)

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