Structure of PDB 8fay Chain D Binding Site BS02
Receptor Information
>8fay Chain D (length=392) Species:
9606
(Homo sapiens) [
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YHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVS
EVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRG
RRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATG
VVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAM
ELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLEPWDQTLGVVNFPRK
ASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEP
SEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALE
GQTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMG
Ligand information
>8fay Chain F (length=11) [
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tgtccacgtct
Receptor-Ligand Complex Structure
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PDB
8fay
Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)
Resolution
1.91 Å
Binding residue
(original residue number in PDB)
L137 Q138 Q139 T140 Q141 V142 R185 P213 G214 G216 Y218 T219 D236 G237 N238 R241
Binding residue
(residue number reindexed from 1)
L54 Q55 Q56 T57 Q58 V59 R102 P130 G131 G133 Y135 T136 D153 G154 N155 R158
Enzymatic activity
Enzyme Commision number
3.2.2.31
: adenine glycosylase.
External links
PDB
RCSB:8fay
,
PDBe:8fay
,
PDBj:8fay
PDBsum
8fay
PubMed
UniProt
Q9UIF7
|MUTYH_HUMAN Adenine DNA glycosylase (Gene Name=MUTYH)
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