Structure of PDB 8epk Chain D Binding Site BS02

Receptor Information
>8epk Chain D (length=235) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDAGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Ligand information
>8epk Chain F (length=31) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guggacuauaccgcguaaugcugccuccacu
<<<<<.......<<.....>>....>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8epk An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		K126 K132 L162 V163 D164 R165 L169 R170 Y177 N178 R233 N236
Binding residue
(residue number reindexed from 1)		K113 K121 L150 V151 D152 R153 L157 R158 Y165 N166 R223 N226
External links
PDB RCSB:8epk, PDBe:8epk, PDBj:8epk
PDBsum8epk
PubMed38985762
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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