Structure of PDB 8e4m Chain D Binding Site BS02

Receptor Information
>8e4m Chain D (length=881) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVNFIQANFDAFGDIQGKYLRLSCDTDSETLYELLTQHWHLKTPNLVIS
NFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISE
NIVAIGIAAWGMVSNRDTLSAQYIMYILDNNHTHLLLVDNGTVEAKLRNQ
LEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVE
QIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSH
LLTVIKMEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASD
EIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLT
ELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSTRHPLQALFI
WAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEE
LANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELAVEATDQ
HFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKL
LWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYA
LVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKS
SLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFL
FAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTP
EWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLV
QEYCNRLNIPFPFVVFAYFYMVVNEDNETLAWEGVMKENYLVKINTKAND
NSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
Ligand information
Ligand IDULO
InChIInChI=1S/C15H33OP/c1-6-7-8-9-10-11-12-13-17(16,14(2)3)15(4)5/h14-15H,6-13H2,1-5H3
InChIKeyDHOTYMJGZIUWRT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCCCC[P](=O)(C(C)C)C(C)C
OpenEye OEToolkits 2.0.7CCCCCCCCCP(=O)(C(C)C)C(C)C
ACDLabs 12.01O=P(CCCCCCCCC)(C(C)C)C(C)C
FormulaC15 H33 O P
Namenonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane
ChEMBL
DrugBank
ZINC
PDB chain8e4m Chain D Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e4m Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Resolution3.44 Å
Binding residue
(original residue number in PDB)		L778 L806 F839 R842 I846 F1013
Binding residue
(residue number reindexed from 1)		L605 L633 F666 R669 I673 F811
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8e4m, PDBe:8e4m, PDBj:8e4m
PDBsum8e4m
PubMed36227998
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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