Structure of PDB 8c6j Chain D Binding Site BS02

Receptor Information
>8c6j Chain D (length=123) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMG
SSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIA
AEEQTAKRRKKRQKLKEKKLLAK
Ligand information
>8c6j Chain I (length=84) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guauguaucaagcuuacaagacugauucuuauguauuuacugaccugugu
uuuuuugcuacuuuuuuucuuuucuccccuuccc
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Receptor-Ligand Complex Structure
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PDB8c6j Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		M68 G73 S76
Binding residue
(residue number reindexed from 1)		M49 G54 S57
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003725 double-stranded RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0003014 renal system process
GO:0006397 mRNA processing
GO:0006469 negative regulation of protein kinase activity
GO:0008380 RNA splicing
GO:0042326 negative regulation of phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c6j, PDBe:8c6j, PDBj:8c6j
PDBsum8c6j
PubMed36867703
UniProtQ9H875|PKRI1_HUMAN PRKR-interacting protein 1 (Gene Name=PRKRIP1)

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