Structure of PDB 8bo1 Chain D Binding Site BS02

Receptor Information

>8bo1 Chain D (length=396) Species: 28173 (Vibrio nigripulchritudo) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KTYQSRDLVLEPIQHPKSIELGMPEVDQSVLAEVAERENVIIGVRPVDEK
SKSLIASKMYSSKGLFVKAKSSDWGPMSGFIPVDQSFAKASARRDLEKFN
EYAEQSILSGNAVSANLYLNQVRIEELVSKYESLTPLELDVDSGMYKTTA
TNGDQTIPFFLNKVTVDDKELWQVHYLREGELAPFKVIGDPVSKQPMTAD
YDLLTVMYTYGDLGPQDKVKQPLTWEQWKESVTYEDLSPKYKARYDNQAL
YEKQDGASLGMVSDRLKELKDVINTSLGRTDGLEMVHHGADDANPYAVMA
DNFPATFFVPKHFFDDDGLGEGKGSIQTYFNVNEQGAVVIQNPQEFSNFQ
QVAINASYRASLNDKWNSGLDSPLFTTKRKLSHDYLDARDEVAKKL

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

8bo1 Chain D Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8bo1 Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.
Resolution	2.501 Å
Binding residue (original residue number in PDB)	D665 D667
Binding residue (residue number reindexed from 1)	D200 D202
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.6.1.1: adenylate cyclase.

Gene Ontology

	Molecular Function
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity

	Cellular Component
GO:0005576	extracellular region

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8bo1, PDBe:8bo1, PDBj:8bo1
PDBsum	8bo1
PubMed	37747912
UniProt	A0A9P1NJI6

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