Structure of PDB 7zr1 Chain D Binding Site BS02

Receptor Information
>7zr1 Chain D (length=780) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYAT
TGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQL
LVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAIL
DAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGD
ELKILKEREVQDKANKERAEKVDRLMAQLTREILEAREKCNELSKQMEEE
SAKIKDKYEQANSFLKIMNDLQTKTEKLEYKKDAIVELRSRIEELPDPDE
VLRNTLDEYEQTINRIVADRDHKAAQFHDLQAELKSARDQHTAKAAEQGK
HQSDKEKYERQLVARERMIREAAERHEIRGYNGDLDDRRIAIFNERIQKI
LNDKRRELERLQKEQKVAAERDAIAQTVSELNMINSEIQEYLDRGGPSSL
AANQRAIANLETQMANLEGEMRELTVQINKLNKEIDNSDAKKRNIADNLT
YRKNLREKDALEREIAELEARNAQEDYDRLIKEAHYLEAHRSKLNADRER
LMGMMSTKDEEFRRLNEEYELDLKDAKAKYKETHIKVETTKAAIEDLGRG
MAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTS
SDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCA
NCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEF
LKYMQCSDFCDDFYRVKRDEKQNSVIVRES
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7zr1 Chain D Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zr1 Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		T41 Q159
Binding residue
(residue number reindexed from 1)		T40 Q158
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043047 single-stranded telomeric DNA binding
GO:0046872 metal ion binding
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0007004 telomere maintenance via telomerase
GO:0032508 DNA duplex unwinding
GO:0070192 chromosome organization involved in meiotic cell cycle
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030870 Mre11 complex
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zr1, PDBe:7zr1, PDBj:7zr1
PDBsum7zr1
PubMed36577401
UniProtG0SHW7|RAD50_CHATD DNA repair protein RAD50 (Gene Name=RAD50)

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