Structure of PDB 7z42 Chain D Binding Site BS02

Receptor Information
>7z42 Chain D (length=715) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYEQNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYL
ADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLS
NESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQT
ISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKL
TWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAK
ECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQ
KTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEM
NLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMK
YVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHL
RGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYC
RVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGD
RVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAE
SRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWL
GFEKEGSKVLESVDE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution2.418 Å
Binding residue
(original residue number in PDB)		L413 E445 Y448 K631 R634
Binding residue
(residue number reindexed from 1)		L406 E438 Y441 K624 R627
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z42, PDBe:7z42, PDBj:7z42
PDBsum7z42
PubMed35605026
UniProtQ5V8Z9

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