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Receptor Information

>7xzh Chain D (length=730) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQD
KMICLPCKWVTKDSCNDSTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAK
YFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRAL
SETVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFIL
IICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLATLFKILASFYIS
LVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLH
LIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDK
LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLY
HTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNL
SAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNE
GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK
TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI
PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPEL
FQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECP
LLKRSGLVVEEDLFNTLPPEVKERLWRADK

Ligand ID

P5S

InChI

InChI=1S/C42H82NO10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49)/t38-,39+/m1/s1

InChIKey

TZCPCKNHXULUIY-RGULYWFUSA-N

SMILES

Software	SMILES
CACTVS 3.370	CCCCCCCCCCCCCCCCCC(=O)OC[CH](CO[P](O)(=O)OC[CH](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC
CACTVS 3.370	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P](O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC
ACDLabs 12.01	O=C(OC(COP(=O)(OCC(C(=O)O)N)O)COC(=O)CCCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCCC
OpenEye OEToolkits 1.7.6	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
OpenEye OEToolkits 1.7.6	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC[C@@H](C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC

Formula

C42 H82 N O10 P

Name

O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine;
phosphatidyl serine

PDB chain

7xzh Chain D Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7xzh cryo-EM structure of human LRRC8A
Resolution	2.78 Å
Binding residue (original residue number in PDB)	A138 F142 F146 R148 L263 R266
Binding residue (residue number reindexed from 1)	A115 F119 F123 R125 L186 R189
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0005225	volume-sensitive anion channel activity
GO:0005253	monoatomic anion channel activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0140360	cyclic-GMP-AMP transmembrane transporter activity

	Biological Process
GO:0001678	intracellular glucose homeostasis
GO:0002329	pre-B cell differentiation
GO:0006820	monoatomic anion transport
GO:0006884	cell volume homeostasis
GO:0006970	response to osmotic stress
GO:0007283	spermatogenesis
GO:0015734	taurine transmembrane transport
GO:0015810	aspartate transmembrane transport
GO:0030154	cell differentiation
GO:0032024	positive regulation of insulin secretion
GO:0034214	protein hexamerization
GO:0034220	monoatomic ion transmembrane transport
GO:0045663	positive regulation of myoblast differentiation
GO:0055085	transmembrane transport
GO:0098656	monoatomic anion transmembrane transport
GO:0140361	cyclic-GMP-AMP transmembrane import across plasma membrane
GO:1902476	chloride transmembrane transport

	Cellular Component
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0034702	monoatomic ion channel complex

PDB	RCSB:7xzh, PDBe:7xzh, PDBj:7xzh
PDBsum	7xzh
PubMed
UniProt	Q8IWT6\|LRC8A_HUMAN Volume-regulated anion channel subunit LRRC8A (Gene Name=LRRC8A)

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Structure of PDB 7xzh Chain D Binding Site BS02