Structure of PDB 7xjv Chain D Binding Site BS02

Receptor Information
>7xjv Chain D (length=509) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CWSYYEGLTPGWLNDFYDVNQITPNPAKDVIELVTRIKIFFNCLNIQRLR
DIEKKLFPYINFEKLETDESAFWHTTTRWNGEVYHASMLEFDPKNHQFLR
SKPINFDTGLSFWENWLHTVTQSGSKGIVISASDVQLNETIRLLKVLRFI
KNDYPIQIVHNADLSQDSMKSIIKYARSLDTAEYPAQELWFLNVHSLLNP
KYSKKFTTYSNKWLALTFSSFEIPILMDSDTVPFVSIKKFYELEEFQKTG
VLFFKDRVISDDLFESSELKILREIVYGCIGLDLEDESKIHEQVEDPVVA
QVLENMFIKKYKHHLESGLVILHKGKHLFSMLTSIALQFSPIAEYFHGDK
DFFWLGELLSNNRFTFHPVDASNIGQLGNVVSKESTGEFYQICSVQLSHT
DRDGSLLWLNGGLNICKKTSWEYDYEHRQRLNDMFQNADELREYYASPVK
LEGIIIPDTSISGWINSGECFLFNYCTLFKEGEFGKLIKFKEDEKLRLSQ
IVDIWNKDI
Ligand information
Ligand IDGDD
InChIInChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1
InChIKeyMVMSCBBUIHUTGJ-GDJBGNAASA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O
ACDLabs 10.04O=P(OC1OC(C(O)C(O)C1O)CO)(O)OP(=O)(O)OCC4OC(n2c3N=C(N)NC(=O)c3nc2)C(O)C4O
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OC4C(C(C(C(O4)CO)O)O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O)N=C(NC2=O)N
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[CH]4O[CH](CO)[CH](O)[CH](O)[CH]4O)[CH](O)[CH]3O
FormulaC16 H25 N5 O16 P2
NameGUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE
ChEMBL
DrugBank
ZINCZINC000008215581
PDB chain7xjv Chain D Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7xjv Crystal Structure of Alpha-1,3-mannosyltransferase MNT2 from Saccharomyces cerevisiae, Mn/GDP-mannose form
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S140 A141 T217 Y218 N220 K221 D237 S238 D239 E325 S326 G327 H356 G357 D358 K359 N419 K426
Binding residue
(residue number reindexed from 1)		S131 A132 T208 Y209 N211 K212 D228 S229 D230 E316 S317 G318 H347 G348 D349 K350 N410 K417
Annotation score4
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0000030 mannosyltransferase activity
GO:0000033 alpha-1,3-mannosyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0000329 fungal-type vacuole membrane
GO:0005794 Golgi apparatus
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0071944 cell periphery

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7xjv, PDBe:7xjv, PDBj:7xjv
PDBsum7xjv
PubMed
UniProtP53059|MNT2_YEAST Alpha-1,3-mannosyltransferase MNT2 (Gene Name=MNT2)

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