Structure of PDB 7wx3 Chain D Binding Site BS02

Receptor Information
>7wx3 Chain D (length=258) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLE
GREVMMVTSGAVAFGKQKLAQELLMSLSMRETLNLEPRAAAAVGQSGLMS
LYDAMFAQYGVKIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINT
NDAVSPPMFIPIKDNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGA
KLMHTYTSDDSNSIMDSKVKAATWALDRGVSVVICNGMQEKAIKTIIGGR
KVGTFFTE
Ligand information
Ligand IDRGP
InChIInChI=1S/C5H10NO7P/c6-3(5(8)9)1-2-4(7)13-14(10,11)12/h3H,1-2,6H2,(H,8,9)(H2,10,11,12)/t3-/m1/s1
InChIKeyPJRXVIJAERNUIP-GSVOUGTGSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCC(=O)O[P](O)(O)=O)C(O)=O
ACDLabs 10.04O=C(OP(=O)(O)O)CCC(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)OP(=O)(O)O)C(C(=O)O)N
CACTVS 3.341N[C@H](CCC(=O)O[P](O)(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C(CC(=O)OP(=O)(O)O)[C@H](C(=O)O)N
FormulaC5 H10 N O7 P
NameGAMMA-GLUTAMYL PHOSPHATE;
5-OXO-5-(PHOSPHONOOXY)-D-NORVALINE
ChEMBL
DrugBank
ZINCZINC000003870044
PDB chain7wx3 Chain D Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wx3 Structural basis of dynamic P5CS filaments.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S103 A105 N204 T205 D207 M213 N233
Binding residue
(residue number reindexed from 1)		S59 A61 N149 T150 D152 M158 N165
Annotation score5
Enzymatic activity
Enzyme Commision number 1.2.1.41: glutamate-5-semialdehyde dehydrogenase.
2.7.2.11: glutamate 5-kinase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wx3, PDBe:7wx3, PDBj:7wx3
PDBsum7wx3
PubMed35286254
UniProtQ9VNW6

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