Structure of PDB 7vok Chain D Binding Site BS02

Receptor Information

>7vok Chain D (length=376) Species: 1773 (Mycobacterium tuberculosis)

KPHVNIGTIGHVDHGKTTLTAAITKVLHETKAFDQIDNAPEERQRGITIN
IAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMP
QTREHVLLARQVGVPYILVADAVDDEELLELVEMEVRELLAAQEFDEDAP
VVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVF
TITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQ
GQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGG
RHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVA
MDEGLRFAIREGGRTVGAGRVTKIIK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7vok Chain D Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7vok The Crystal structure of EF-Tu and GDP from Mycobacterium tuberculosis
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): T26 P85
• Binding residue (residue number reindexed from 1): T17 P69
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0035375 zymogen binding

Biological Process

• GO:0001666 response to hypoxia
• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0010039 response to iron ion

Cellular Component

• GO:0005576 extracellular region
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:7vok, PDBe:7vok, PDBj:7vok
• PDBsum: 7vok
• PubMed: 36192483
• UniProt: P9WNN1|EFTU_MYCTU Elongation factor Tu (Gene Name=tuf)