Structure of PDB 7u5h Chain D Binding Site BS02

Receptor Information

>7u5h Chain D (length=422) Species: 9913 (Bos taurus)

RKEAVQAAARELLKFVNRSPSPFHAVAECRSRLLQAGFHELKETESWDIK
PESKYFLTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRS
QVGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRLEQRLVHVDR
PILRIPHLAIHLQNMEMHLVPILATSIQEELEHSVLTSLLCAHLGLSPED
ILEMELCLADTQPAVLGGAYEEFIFAPRLDNLHSCFCALQALIDSCSAPA
SLAADPHVRMIALYDNEEVGSESAQGAQSLLTELVLRRISASPQHLTAFE
EAIPKSYMISADMAHAVHPNYRPLFHKGPVIKVNSKQRYASNAVSEALIR
EVASSVGVPLQDLMVTIGPILASRLGLRVLDLGSPQLAMHSIRETACTTG
VLQTITLFKGFFELFPSLSRSL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7u5h Chain D Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7u5h Toward structural-omics of the bovine retinal pigment epithelium.
• Resolution: 3.32 Å
• Binding residue (original residue number in PDB): H90 D260 D342
• Binding residue (residue number reindexed from 1): H85 D230 D312
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.11.21: aspartyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7u5h, PDBe:7u5h, PDBj:7u5h
• PDBsum: 7u5h
• PubMed: 36577381
• UniProt: Q2HJH1|DNPEP_BOVIN Aspartyl aminopeptidase (Gene Name=DNPEP)