Structure of PDB 7r3b Chain D Binding Site BS02

Receptor Information

>7r3b Chain D (length=369) Species: 1590 (Lactiplantibacillus plantarum)

RHLFTSESVSEGHPDKIADQISDAILDAMLAQDPQARVAVETSVTTGLVL
VFGEVSTKAYVDIQKVVRDTIKSIGYVDGQYGFDGDNCAVLVSLDEQSIG
AGDQGMMFGYAINETPELMPLPIALSHRLMRKIAALRKDGTIKWLRPDAK
AQVTVEYDEDNQPKRIDTVVLSTQHDPDVDLDTIRQTVIDQVIKAVLPAD
LLDDQTKYLVNPTGRFVIGGPQGDAGLTGRKVIVDTYGGFAHHGGGAFSG
KDATKVDRSASYAARYIAKNVVAAGLADQVEVQLAYAIGVAEPVSIAVDT
AGTGKVSDEALINAIRENFDLRPAGIIKMLDLQRPIYRQTAAYGHFGRTD
IDLPWEHTDKVDALKAAFK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7r3b Chain D Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7r3b Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure-function constrains.
• Resolution: 2.82 Å
• Binding residue (original residue number in PDB): D18 R256
• Binding residue (residue number reindexed from 1): D15 R230
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.6: methionine adenosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004478 methionine adenosyltransferase activity
• GO:0005524 ATP binding
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006556 S-adenosylmethionine biosynthetic process
• GO:0006730 one-carbon metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7r3b, PDBe:7r3b, PDBj:7r3b
• PDBsum: 7r3b
• PubMed: 35762725
• UniProt: Q88XB8|METK_LACPL S-adenosylmethionine synthase (Gene Name=metK)