Structure of PDB 7qhh Chain D Binding Site BS02

Receptor Information
>7qhh Chain D (length=404) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL
VSRFSPYEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLII
ISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKL
KNKWWYDKGECGAKDKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC
YKSR
Ligand information
Ligand ID79N
InChIInChI=1S/C19H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-17-18(21)16-20/h9-10,18,20-21H,2-8,11-17H2,1H3/b10-9-/t18-/m0/s1
InChIKeyOWGMAJRKMYGYBQ-LPADLIQXSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCCC\C=C/CCCCCC(=O)OC[C@@H](O)CO
ACDLabs 12.01O=C(OCC(O)CO)CCCCC\C=C/CCCCCCCC
CACTVS 3.385CCCCCCCCC=CCCCCCC(=O)OC[CH](O)CO
OpenEye OEToolkits 1.7.6CCCCCCCCC=CCCCCCC(=O)OCC(CO)O
OpenEye OEToolkits 1.7.6CCCCCCCC/C=C\CCCCCC(=O)OC[C@H](CO)O
FormulaC19 H36 O4
Name(2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate
ChEMBL
DrugBank
ZINCZINC000221534416
PDB chain7qhh Chain D Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qhh Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Y523 M527 Y533 F584
Binding residue
(residue number reindexed from 1)		Y131 M135 Y141 F172
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qhh, PDBe:7qhh, PDBj:7qhh
PDBsum7qhh
PubMed35136046
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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