Structure of PDB 7qcd Chain D Binding Site BS02

Receptor Information
>7qcd Chain D (length=326) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVTGDATAKYLLQYILSARGICHENALILALMRLETDASTLNTEWSIQQW
VDKLNDYINAINVKLNLLGYKIIRINHGIGRNAVTLKAKQNFESFEDNTA
IRAHNNDYAVLQSIVLPESNRFFVYVNLASTEETKLATRFNQNEIEFMKW
AIEQFMISGETIVEGPALETSIIVKEVNRILVAATGDSNLAKWRKFSTFT
VGSTNLFQFQELTATDIEDLLLRLCELKWFYRTQEGKFGIDLRCIAELEE
YLTSMYNLNTCQNCHKLAIQGVRCGNESCREENEETGENSLSQIWHVDCF
KHYITHVSKNCDRCGSSLITEGVYVI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7qcd Chain D Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7qcd Cryo-EM structure of the Smc5/6 holo-complex.
Resolution8.0 Å
Binding residue
(original residue number in PDB)		C289 C321 R323 C324
Binding residue
(residue number reindexed from 1)		C279 C311 R313 C314
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019789 SUMO transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006310 DNA recombination
GO:0016925 protein sumoylation
GO:0032204 regulation of telomere maintenance
GO:0140588 chromatin looping
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0030915 Smc5-Smc6 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qcd, PDBe:7qcd, PDBj:7qcd
PDBsum7qcd
PubMed35993814
UniProtQ07913|NSE1_YEAST Non-structural maintenance of chromosomes element 1 (Gene Name=NSE1)

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