Structure of PDB 7p0m Chain D Binding Site BS02

Receptor Information
>7p0m Chain D (length=531) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTR
NYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQ
LRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIK
GHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLE
LLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVS
GYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGV
RNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDV
TPPGVVMGLAWTAMGGSTLFVETSLRRKDGSLEVTGQLGEVMKESARIAY
TFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLA
MGRPVRQNLAMTGEVSLTGKILPVGGIKEATIAAKRAGVTCIVLPAENKK
DFYDLAAFITEGLEVHFVEHYREIFDIAFPD
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7p0m Chain C Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7p0m A dual allosteric pathway drives human mitochondrial Lon
Resolution2.75 Å
Binding residue
(original residue number in PDB)		E614 R652
Binding residue
(residue number reindexed from 1)		E205 R243
Annotation score5
Enzymatic activity
Enzyme Commision number 3.4.21.53: endopeptidase La.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
GO:0016887 ATP hydrolysis activity
GO:0042731 PH domain binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0043560 insulin receptor substrate binding
GO:0043565 sequence-specific DNA binding
GO:0051880 G-quadruplex DNA binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0001666 response to hypoxia
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0007005 mitochondrion organization
GO:0030163 protein catabolic process
GO:0032042 mitochondrial DNA metabolic process
GO:0034599 cellular response to oxidative stress
GO:0035694 mitochondrial protein catabolic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0051131 chaperone-mediated protein complex assembly
GO:0051603 proteolysis involved in protein catabolic process
GO:0070407 oxidation-dependent protein catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7p0m, PDBe:7p0m, PDBj:7p0m
PDBsum7p0m
PubMed
UniProtP36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)

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