Structure of PDB 7lpj Chain D Binding Site BS02

Receptor Information
>7lpj Chain D (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE
LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLL
PALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lpj Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker.
Resolution2.56 Å
Binding residue
(original residue number in PDB)		Y128 N174 R177 N222 N226 N229 A230 F266 M271 K276 W280 H309
Binding residue
(residue number reindexed from 1)		Y86 N132 R135 N180 N184 N187 A188 F224 M229 K234 W238 H267
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7lpj, PDBe:7lpj, PDBj:7lpj
PDBsum7lpj
PubMed34188778
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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