Structure of PDB 7lma Chain D Binding Site BS02

Receptor Information
>7lma Chain D (length=187) Species: 5911 (Tetrahymena thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRIYSSIEEIIQQAQASEIGQKKEFYVYGNLVSIQMKNKLYYYRCTCQGK
SVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPVMIFDQQSSQL
INQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENK
EFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7lma Chain D Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7lma Structures of telomerase at several steps of telomere repeat synthesis.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C555 C572 C575
Binding residue
(residue number reindexed from 1)		C45 C62 C65
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0043047 single-stranded telomeric DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007004 telomere maintenance via telomerase
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lma, PDBe:7lma, PDBj:7lma
PDBsum7lma
PubMed33981033
UniProtD2CVN6|TEB1_TETTS Telomeric repeat-binding subunit 1 (Gene Name=TEB1)

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