Structure of PDB 7f75 Chain D Binding Site BS02

Receptor Information
>7f75 Chain D (length=1142) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKDGLFCERI
FGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPV
SHIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLS
EKEYRAYLDKYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQ
RRTRAIKRLEVLEAFRNSGNKPSWMILDVLPVIPPELRPMVQLDGGRFAT
SDLNDLYRRVINRNNRLKRLLDLGAPSIIVQNEKRMLQEAVDALIDNGRR
GRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPHLK
MYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIERVQPEVWDVL
ESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADFD
GDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYY
LTLERAGAVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLQRSKLLI
TTVGKLVFNEILPESFPYMNEPTKSNIEEDVKAVIAQQPINAPFKKGILG
KIIAEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQE
ILEEAQSKVDNVMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLD
ELNPIYMMSDSGARGNASNFTQLAGMRGLMANPAGRIIELPIKSSFREGL
TVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIIRETDCGTD
RGILAKPLKEGTETIERLEERLIGRFARKQVKHPETGEVLVNENELIDED
KALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVEVGEAVGI
IAAQSIGEPGTQLTGLPRIQELFEARNPATITEIDGTVVEINEVRDKQQE
IVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSIDPKELLKVTDL
TTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVGDTDVLPGTL
LDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETT
RVLTDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKP
Ligand information
>7f75 Chain K (length=63) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgcatccgtgagtcgagggtaataaagcatctcccattcgttcacgctat
tttaatgcttaca
Receptor-Ligand Complex Structure
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PDB7f75 Structural basis of transcription activation by the global regulator Spx.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R248 R300 K323 R341 A415 P416 T794 A795
Binding residue
(residue number reindexed from 1)		R247 R299 K322 R340 A414 P415 T773 A774
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f75, PDBe:7f75, PDBj:7f75
PDBsum7f75
PubMed34530448
UniProtP37871|RPOC_BACSU DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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