Structure of PDB 7b16 Chain D Binding Site BS02

Receptor Information
>7b16 Chain D (length=643) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAI
ENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHQFSDFTPDIT
PIILAAHTNNYEIIKMLVQKGVSVPQPHEVVDSLRHSRSRLNIYKALASP
SLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLL
DQTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDE
RHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASY
LTFLFLLLLASQHIVNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGG
FQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTL
VAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCL
VLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSI
FGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQ
HIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIAENVRLNHQYQEVLRN
LVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7b16 Chain D Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b16 Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		E417 N435 D438
Binding residue
(residue number reindexed from 1)		E342 N360 D363
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b16, PDBe:7b16, PDBj:7b16
PDBsum7b16
PubMed33236980
UniProtU3N7D8

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