Structure of PDB 7at8 Chain D Binding Site BS02

Receptor Information
>7at8 Chain D (length=113) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLV
REIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLCAIHAKRVTIMP
KDIQLARRIRGER
Ligand information
>7at8 Chain U (length=156) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atacaggatgtatatatatctgacacgtgcctggagactagggagtaatc
cccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggt
gctagagctgtctacgaccaattgagcggcctcggcaccgggattctcca
gtatga
Receptor-Ligand Complex Structure
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PDB7at8 Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		R40 Y41 P43 G44 V46 R49 R63 R69
Binding residue
(residue number reindexed from 1)		R19 Y20 P22 G23 V25 R28 R42 R48
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7at8, PDBe:7at8, PDBj:7at8
PDBsum7at8
PubMed33211010
UniProtP84233|H32_XENLA Histone H3.2

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