Structure of PDB 6z48 Chain D Binding Site BS02

Receptor Information
>6z48 Chain D (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETVGK
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQFG
Ligand information
>6z48 Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB6z48 Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		E23 G25 M26 W29 D116 H119 P120 C122 L129C Y134 K135 G136 R137 N159 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 G10 M11 W14 D113 H116 P117 C119 L129 Y134 K135 G136 R137 N160 K208 R214 W215
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z48, PDBe:6z48, PDBj:6z48
PDBsum6z48
PubMed35780129
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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