Structure of PDB 6wqx Chain D Binding Site BS02

Receptor Information
>6wqx Chain D (length=230) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGY
RHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIE
GSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSN
MLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETV
FEAFLKSYSTSSKKARPVLKKLDEVRLRGR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6wqx Chain D Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wqx Crystal structure of the human PRPK-TPRKB complex.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		N167 D183
Binding residue
(residue number reindexed from 1)		N150 D166
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.-.-
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0008033 tRNA processing
GO:0016310 phosphorylation
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0000408 EKC/KEOPS complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wqx, PDBe:6wqx, PDBj:6wqx
PDBsum6wqx
PubMed33547416
UniProtQ96S44|PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (Gene Name=TP53RK)

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