Structure of PDB 6wmr Chain D Binding Site BS02

Receptor Information
>6wmr Chain D (length=1159) Species: 376619 (Francisella tularensis subsp. holarctica LVS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKKFDIIKISLASPEVIRSWSHGEVKKPETINYRTFKPERDGLFCAKIFG
PIKDYECLCGKYKRLKHRGVVCERCGVEVEQAKVRRERMGHIDLVCPVVH
IWYLKSLPSRIGLFLDMPLKNVEKVLYFESYIVTDPGMTPLEKKQLLTDE
EYAEALENYGYEFEASMGAEAIRDLLADTDIESEIELLQAECEESKSTAK
KEKAIKRLRLLETFQASGNKPEWMVMTVLPVLPPDLRPLVPIEGGRFATS
DLNDLYRRVINRNNRLKKLLDLNAPDIIVRNEKRMLQEAVDALLDNGRRG
RAVTGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPSLRL
HECGLPKKMALELFKPFVYSKLRLGGHATTIKQAKRMVELEEAVVWDILE
TVINEHPVLLNRAPTLHRLGIQAFEPRLIEGKAIQLHPLVCAAFNADFDG
DQMAVHVPLTVESQLEARVLMMSTNNILSPASGQPIITPTQDIVLGLYYI
TREKEGARGEGKLFSSYEDVSRAYNSGTIDIHAKIKLRIDRQVFDTKGNT
YNEKGVVNTTVGRALLLNILPEGLSFSLLNKVLVKKEISKIINQAFRVLG
GKATVVLADKLMYAGFKYSTLSGVSVGVDDMTIPDNKEAKIEEAEKEIKQ
ITEQYQSSLITENERYNNIINIWSKTSDEVGASMMDAISKDTVSINGEKK
EIESFNSVYMMAKSGARGSYNQMRQLAGMRGLMAKPDGTMIETAITANFR
EGLSVLQYFTSTHGARKGLADTALKTANAGYLTRRLVDVAQDLVVIEEDC
GTDDGLMFSAIVEDGEVKVPLVERALGRTLAADVVTEKGVVLLEAGTLLD
ENLVELLDDNGIDMIKVRSPITCKTRRGLCAKCYGRDLARERQVNVGESV
GVIAAQSIGEPGTQLTMGLPRVAELFEARRPKDAAILSPCDGMVRLGNRD
TKEKQRIEIIDKNGHIVEEILLPKSRHLVVFDGEQVSRGDVLADGPTDPH
DLLKYKGLEEFADYILIEAQSVYRMQGVVINDKHIETIVRQMLRKAVILD
EGDSKFVKDESIELVRILEENDKLRKQGKKEVEYELVLMGITRSSLSTES
FLSAASFQETTRVLTEASINSQIDNLRGLKENVLIGRLIPAGTGLAVRKE
SAKIEKMRE
Ligand information
Receptor-Ligand Complex Structure
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PDB6wmr Structural Basis for Virulence Activation of Francisella tularensis.
Resolution3.46 Å
Binding residue
(original residue number in PDB)		T209 E1315
Binding residue
(residue number reindexed from 1)		T198 E1109
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wmr, PDBe:6wmr, PDBj:6wmr
PDBsum6wmr
PubMed33217319
UniProtQ2A1M8|RPOC_FRATH DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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