Structure of PDB 6waa Chain D Binding Site BS02

Receptor Information
>6waa Chain D (length=637) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILN
TWEVSSDEVLASQEVHDISVAIGIDPDSDYGKICILADADSDGLHIATLL
CALFVRHFRTLVKEGHVYVALPPLYALTEEEKTGVRFKGLGEMNPMQLRE
TTLDPNTRRLVQLISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEKGRLAL
HEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPD
DPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPAR
LPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIV
QGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVALPHQVSGAKVLEQIA
AQMRNKKLPMVDDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLL
EILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIR
TEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKER
DQLQAILASERKMNNLLKKELQADADAFGDDRRSPLH
Ligand information
Receptor-Ligand Complex Structure
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PDB6waa Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G443 D495 R1029 V1041 H1075 H1077 G1078 A1081 T1170 I1172
Binding residue
(residue number reindexed from 1)		G46 D92 R219 V231 H265 H267 G268 A271 T360 I362
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6waa, PDBe:6waa, PDBj:6waa
PDBsum6waa
PubMed32634310
UniProtB5XU60

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