Structure of PDB 6u8x Chain D Binding Site BS02
Receptor Information
>6u8x Chain D (length=291) Species:
9606
(Homo sapiens) [
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LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Ligand information
>6u8x Chain F (length=25) [
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catguagtctaattagactgcatgg
Receptor-Ligand Complex Structure
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PDB
6u8x
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Resolution
2.95064 Å
Binding residue
(original residue number in PDB)
V657 P659 R823 G824
Binding residue
(residue number reindexed from 1)
V95 P97 R261 G262
Enzymatic activity
Enzyme Commision number
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168
methyltransferase activity
View graph for
Molecular Function
External links
PDB
RCSB:6u8x
,
PDBe:6u8x
,
PDBj:6u8x
PDBsum
6u8x
PubMed
32620778
UniProt
Q9UBC3
|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)
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