Structure of PDB 6u6z Chain D Binding Site BS02
Receptor Information
>6u6z Chain D (length=420) Species:
9606
(Homo sapiens) [
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GKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNNGIDVDKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRA
YQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLT
DNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDY
ESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDAEQLIRVYCKKVDRKSL
YAARQYFVQWCADRNFTKPQ
Ligand information
>6u6z Chain H (length=4) [
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tgct
Receptor-Ligand Complex Structure
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PDB
6u6z
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
Y155 V156 H376 R451
Binding residue
(residue number reindexed from 1)
Y41 V42 H253 R328
Enzymatic activity
Enzyme Commision number
3.1.5.-
External links
PDB
RCSB:6u6z
,
PDBe:6u6z
,
PDBj:6u6z
PDBsum
6u6z
PubMed
33531504
UniProt
Q9Y3Z3
|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)
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