Structure of PDB 6tyg Chain D Binding Site BS02

Receptor Information
>6tyg Chain D (length=1262) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPT
RDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIW
YFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEM
AVERKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREM
RQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGA
MGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAFQQS
GNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLK
RLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDL
LKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPF
VMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLH
RLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEA
RILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGD
HPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGHSG
WQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYP
MIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADK
VEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIVDS
GATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHG
ARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERA
PDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAA
GITQVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGE
PGTQLTGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPD
DGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPH
EVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIID
SGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDS
WLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRN
IAVQPTEEARAA
Ligand information
Receptor-Ligand Complex Structure
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PDB6tyg RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		P111 S112 Y116 P122 K123 R291 K294 R1038
Binding residue
(residue number reindexed from 1)		P106 S107 Y111 P117 K118 R286 K289 R1019
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tyg, PDBe:6tyg, PDBj:6tyg
PDBsum6tyg
PubMed32127479
UniProtP9WGY7|RPOC_MYCTU DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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