Structure of PDB 6rxm Chain D Binding Site BS02

Receptor Information
>6rxm Chain D (length=227) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIGLWEEHRVEDVGTPEGFDRDPELVQAFYNARR
RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAGNTNVIHM
HGELLKVRCSQSGQALDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG
MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV
GNEFAEKYYGPASQVVPEFVEKLLKGL
Ligand information
>6rxm Chain J (length=8) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGAKRHRK
Receptor-Ligand Complex Structure
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PDB6rxm Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.92 Å
Binding residue
(original residue number in PDB)		H147 V188 W189 F190 G191 E192 M193 Y201 G217 H218 V219 Y220 P221 Q245
Binding residue
(residue number reindexed from 1)		H101 V142 W143 F144 G145 E146 M147 Y155 G171 H172 V173 Y174 P175 Q199
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxm, PDBe:6rxm, PDBj:6rxm
PDBsum6rxm
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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