Structure of PDB 6n9a Chain D Binding Site BS02

Receptor Information
>6n9a Chain D (length=330) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGRMRVLGIETSCDETAVAVLDDGKNVVVNFTVSQIEVHQKFGGVVPEVA
ARHHLKNLPILLKKAFEKVPPETVDVVAATYGPGLIGALLVGLSAAKGLA
ISLEKPFVGVNHVEAHVQAVFLANPDLKPPLVVLMVSGGHTQLMKVDEDY
SMEVLGETLDDSAGEAFDKVARLLGLGYPGGPVIDRVAKKGDPEKYSFPR
PMLDDDSYNFSFAGLKTSVLYFLQREKGYKVEDVAASFQKAVVDILVEKT
FRLARNLGIRKIAFVGGVAANSMLREEVRKRAERWNYEVFFPPLELCTDN
ALMVAKAGYEKAKRGMFSPLSLNADPNLNV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6n9a Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6n9a Conformational communication mediates the reset step in t6A biosynthesis.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H109 H113 H137 D296
Binding residue
(residue number reindexed from 1)		H112 H116 H140 D299
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0008033 tRNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6n9a, PDBe:6n9a, PDBj:6n9a
PDBsum6n9a
PubMed31114923
UniProtQ9WXZ2|TSAD_THEMA tRNA N6-adenosine threonylcarbamoyltransferase (Gene Name=tsaD)

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