Structure of PDB 6mfb Chain D Binding Site BS02

Receptor Information
>6mfb Chain D (length=386) Species: 7159 (Aedes aegypti) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFTPPPSSLRGPLVIPDKIMMGPGPSNCSKRVLAALNNTCLSNFHDELF
QVIDEVKDGLRYIFQTENRTTMCITGSAHTGMEALLCNLLEEGDIVLIAN
NGIWAERAINMATRYGADVRVLEGPADKPFSMTDFKKAIEQHRPKCLFVV
HGDSSSGLLQPLEGLGKICHDYDCLLLVDAVASLCGVPFYMDKWEIDGVY
TGSQKVLGAPPGITPISISPKALEVIRSRKTPSKVFYWDLLILGNYWGCY
DEQKRYHHTVPSNLIFALREAIAQIAEEGLEPVIRRRQECAEQMYRGLQA
MGLEIFVKDPEYRLPTVTCIMIPKGVNWWKVSEYAMNNFSLEIQGGFGPT
MGIAWRAGIMGESSTLQRVNFYLYAFKESLKATHPD
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain6mfb Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6mfb Crystal structure of 3-hydroxykynurenine transaminase from Aedes aegypti
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S77 A78 H79 W104 S154 D179 V181 Q204 K205
Binding residue
(residue number reindexed from 1)		S77 A78 H79 W104 S154 D179 V181 Q204 K205
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
2.6.1.63: kynurenine--glyoxylate transaminase.
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0047315 kynurenine-glyoxylate transaminase activity
Biological Process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mfb, PDBe:6mfb, PDBj:6mfb
PDBsum6mfb
PubMed
UniProtQ0IG34|HKT_AEDAE 3-hydroxykynurenine transaminase (Gene Name=HKT)

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