Structure of PDB 6lwa Chain D Binding Site BS02

Receptor Information
>6lwa Chain D (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QNPDLLELCHSVPKEVVQLGGKGYGGEEDFAAFRAWLRCYGMPGMSSLQD
RHGRTIWFQGDPGPLAP
Ligand information
Receptor-Ligand Complex Structure
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PDB6lwa DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		R95 H96 R118 R119 F120
Binding residue
(residue number reindexed from 1)		R94 H95 R117 R118 F119
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwa, PDBe:6lwa, PDBj:6lwa
PDBsum6lwa
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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