Structure of PDB 6lc1 Chain D Binding Site BS02

Receptor Information

>6lc1 Chain D (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKR
RRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLP

Ligand information

>6lc1 Chain F (length=26) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agtgatatttacctccaaatgccagg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6lc1 Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.
Resolution	3.12 Å
Binding residue (original residue number in PDB)	E285 F290 R293 R316 N317 Q320 R323 R345 R346 G347 R348 P350
Binding residue (residue number reindexed from 1)	E21 F26 R29 R52 N53 Q56 R59 R81 R82 G83 R84 P86
Binding affinity	PDBbind-CN: Kd=135.33nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Biological Process

External links

PDB	RCSB:6lc1, PDBe:6lc1, PDBj:6lc1
PDBsum	6lc1
PubMed	31822342
UniProt	P22736\|NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Gene Name=NR4A1)

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