Structure of PDB 6k5h Chain D Binding Site BS02

Receptor Information
>6k5h Chain D (length=288) Species: 763924 (Phytophthora capsici LT1534) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTHSDGTVLHLGLRAGQVANRIVSVGSLGRAKVLAQLLDEGHFETFESAR
GFTTYSGKVKGVPVSIVATGMGVPNMDFVVRETRAVVNGPMTIIRFGTCG
AVREEVPPGSVVVNGKGSIMVTRNPDAFFPGASEEDCYRVSRVMPSSSTL
SKALVASMEDKLTALRAEPVIAASSDCDALRVFDGLNATACSFYSSQGRL
DSNFDDRNEKLVEDLTTAHPDLYTVEMETFHLLDLAQRSRGSIQATAAVL
VVANRLSGQIVESEVLEALESFWGGVVLQTIVSTPLDA
Ligand information
Ligand IDURA
InChIInChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChIKeyISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC=CC(=O)N1
ACDLabs 10.04O=C1C=CNC(=O)N1
OpenEye OEToolkits 1.5.0C1=CNC(=O)NC1=O
FormulaC4 H4 N2 O2
NameURACIL
ChEMBLCHEMBL566
DrugBankDB03419
ZINCZINC000000895045
PDB chain6k5h Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6k5h Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		F202 Q206 R208
Binding residue
(residue number reindexed from 1)		F193 Q197 R199
Annotation score5
Enzymatic activity
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:6k5h, PDBe:6k5h, PDBj:6k5h
PDBsum6k5h
PubMed32493959
UniProtA0A410UCT3

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