Structure of PDB 6ii6 Chain D Binding Site BS02

Receptor Information

>6ii6 Chain D (length=164) Species: 9606 (Homo sapiens)

GKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISF
TVWDVGGLDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAE
DELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSG
DGLYEGLDWLANQL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6ii6 Chain D Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ii6 Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): T31 T48
• Binding residue (residue number reindexed from 1): T18 T35
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding

Biological Process

• GO:0006886 intracellular protein transport
• GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
• GO:0015031 protein transport
• GO:0016192 vesicle-mediated transport

Cellular Component

• GO:0000139 Golgi membrane
• GO:0005737 cytoplasm
• GO:0005794 Golgi apparatus
• GO:0005886 plasma membrane
• GO:0048471 perinuclear region of cytoplasm
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6ii6, PDBe:6ii6, PDBj:6ii6
• PDBsum: 6ii6
• PubMed: 31427506
• UniProt: P61204|ARF3_HUMAN ADP-ribosylation factor 3 (Gene Name=ARF3)