Structure of PDB 6fqs Chain D Binding Site BS02

Receptor Information
>6fqs Chain D (length=189) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVY
Ligand information
Receptor-Ligand Complex Structure
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PDB6fqs A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		D437 K460
Binding residue
(residue number reindexed from 1)		D21 K44
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqs, PDBe:6fqs, PDBj:6fqs
PDBsum6fqs
PubMed29538767
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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