Structure of PDB 6f57 Chain D Binding Site BS02

Receptor Information
>6f57 Chain D (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQG
KIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGR
LFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVM
IDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSK
VRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSN
MSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f57 Structural basis for DNMT3A-mediated de novo DNA methylation.
Resolution3.098 Å
Binding residue
(original residue number in PDB)		S708 C710 N711 S714 V716 N717 E756 V758 R792 R831 T832 T834 T835 R836 K844 G890
Binding residue
(residue number reindexed from 1)		S79 C81 N82 S85 V87 N88 E127 V129 R163 R202 T203 T205 T206 R207 K215 G261
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6f57, PDBe:6f57, PDBj:6f57
PDBsum6f57
PubMed29414941
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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