Structure of PDB 6f2b Chain D Binding Site BS02

Receptor Information
>6f2b Chain D (length=312) Species: 479433 (Catenulispora acidiphila DSM 44928) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEVSAILVLTSSEASTLERVADLVTAHALYAAHDFCAQAQLAAAELPSRV
VARLQEFAWGDMNEGHLLIKGLPQVRSLPPTPTSNVHAVAATTPMSRYQA
LINECVGRMIAYEAEGHGHTFQDMVPSELELHTEQAFSPLRPDFVSLACL
RGDPRALTYLFSARQLVATLTTQEIAMLREPMWTTTVDESFLAEGRTFLL
GFERGPIPILSGADDDPFIVFDQDLMRGISAPAQELQQTVIRAYYAERVS
HCLAPGEMLLIDNRRAVHGRSIFAPRFDGADRFLSRSFIVADGSRSRHAR
SSFGRVVSARFS
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain6f2b Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f2b Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		L175 T204 H314 R316 R328 R332
Binding residue
(residue number reindexed from 1)		L129 T158 H268 R270 R282 R286
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:6f2b, PDBe:6f2b, PDBj:6f2b
PDBsum6f2b
PubMed30410048
UniProtC7QJ42|LYS3O_CATAD L-lysine 3-hydroxylase (Gene Name=Caci_0231)

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