Structure of PDB 6f1c Chain D Binding Site BS02

Receptor Information
>6f1c Chain D (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENC
AYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFS
NEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLH
DDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVV
VTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKS
NALDIIFQTDLTGQKKGWKLRYHGDP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6f1c Chain D Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f1c Structure of the C1r-C1s interaction of the C1 complex of complement activation.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		D116 I117 E119 F135 G137 G138
Binding residue
(residue number reindexed from 1)		D116 I117 E119 F135 G137 G138
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.42: complement subcomponent C1s.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f1c, PDBe:6f1c, PDBj:6f1c
PDBsum6f1c
PubMed29311313
UniProtP09871|C1S_HUMAN Complement C1s subcomponent (Gene Name=C1S)

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