Structure of PDB 6exh Chain D Binding Site BS02

Receptor Information
>6exh Chain D (length=350) Species: 239 (Flavobacterium sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTLEIPTSPLIIKITQQERNILSNVGNLLVKAFGNYENPDYIASLHLHAF
QLLPERITRILSQFGSDFSAEQYGAIVFQGLIEVDQDDLGPTPPNWQGAD
YGKLNKYGFICSLLHGAVPSKPVQYYAQRKGGGLLHAVIPDEKMAATQTG
SGSKTDLFVHTEDAFLSNQADFLSFLYLRNEERVPSTLYSIRSHGKMNPV
MKKLFEPIYQCPKDANYNSGPTASVLYGNRELPFIRFDAAEQIFNENAGQ
TSEALGNLMDFWDEAKTLINSDYIPNSGDLIFVNNHLCAHGRSAFIAGQR
IENGEIIKCERRQMLRMMSKTSLIHIRSVTRTDDPYFIMEEHLGKIFDLD
Ligand information
Ligand IDLYO
InChIInChI=1S/C6H14N2O3/c7-2-1-4(9)3-5(8)6(10)11/h4-5,9H,1-3,7-8H2,(H,10,11)/t4-,5-/m0/s1
InChIKeyASYBZHICIMVQII-WHFBIAKZSA-N
SMILES
SoftwareSMILES
CACTVS 3.370NCC[C@H](O)C[C@H](N)C(O)=O
CACTVS 3.370NCC[CH](O)C[CH](N)C(O)=O
OpenEye OEToolkits 1.7.0C(CN)C(CC(C(=O)O)N)O
ACDLabs 12.01O=C(O)C(N)CC(O)CCN
OpenEye OEToolkits 1.7.0C(CN)C(C[C@@H](C(=O)O)N)O
FormulaC6 H14 N2 O3
Name4-HYDROXY-LYSINE
ChEMBL
DrugBank
ZINCZINC000013511406
PDB chain6exh Chain D Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6exh Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q144 T165 G166 H176 D230 D260
Binding residue
(residue number reindexed from 1)		Q128 T149 G150 H160 D214 D238
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:6exh, PDBe:6exh, PDBj:6exh
PDBsum6exh
PubMed30410048
UniProtJ3BZS6|LYS4O_FLASC L-lysine 4-hydroxylase (Gene Name=PMI10_03368)

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