Structure of PDB 6eur Chain D Binding Site BS02

Receptor Information
>6eur Chain D (length=344) Species: 1144313 (Flavobacterium sp. CF136) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLEIPTSPLIIKITQQERNILSNVGNLLVKAFGNYENPDYIASLHLHAFQ
LLPERITRILSQFGSDFSAEQYGAIVFQGLIEVDQDDLGPTPPNWQGADY
GKLNKYGFICSLLHGAVPSKPVQYYAQRKGGGLLHAVIPDEKMAATQTGS
GSKTDLFVHTEDAFLSNQADFLSFLYLRNEERVPSTLYSIRSHGKMNPVM
KKLFEPIYQCPKDGPTASVLYGNRELPFIRFDAAEQIFNENAGQTSEALG
NLMDFWDEAKTLINSDYIPNSGDLIFVNNHLCAHGRSAFIAGQRIENGEI
IKCERRQMLRMMSKTSLIHIRSVTRTDDPYFIMEEHLGKIFDLD
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain6eur Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6eur Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L173 H176 E178 F191 R314 R334 M336 R338
Binding residue
(residue number reindexed from 1)		L156 H159 E161 F174 R286 R306 M308 R310
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:6eur, PDBe:6eur, PDBj:6eur
PDBsum6eur
PubMed30410048
UniProtJ3BZS6|LYS4O_FLASC L-lysine 4-hydroxylase (Gene Name=PMI10_03368)

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