Structure of PDB 6erg Chain D Binding Site BS02

Receptor Information
>6erg Chain D (length=503) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRD
LLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRF
QDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSA
KASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRV
HFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKAL
KPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEK
EETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTL
FSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPG
FQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENP
VLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYP
PDY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6erg XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y32 R252 A255 S257 T300 R403 R444
Binding residue
(residue number reindexed from 1)		Y1 R221 A224 S226 T269 R372 R413
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6erg, PDBe:6erg, PDBj:6erg
PDBsum6erg
PubMed30291363
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

[Back to BioLiP]