Structure of PDB 6drj Chain D Binding Site BS02

Receptor Information
>6drj Chain D (length=1266) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CSLASWIKENIKKKECVRETPTDAFGDISFGGLGQKTGKYVRVSSDTSCE
NLYQLMTEQWKLRSPNLLISVTGGAKNFYIKTHLKDKFRRGLIKVAQTTG
AWILTGGTHAGVMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRST
LIHPEGRFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELR
ARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNTIYNSMLNHTPCVV
LEGSGRLADVIAHVASVPVSKVTMALINRLLKRFFMQEYKNFTELQIIEW
TKKIQDILRMPHLLTVFRIDEDKNYDVDVAILQALLKASRSDEHAGRHCW
ERQLELAVAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEFVRL
LLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKRVQGLPGSRKVCLS
HVSEEVRHLLGSFTQPLYIASRYKPADTVWDPGRDLFLWAVVQNNRELAE
IGWEQCRDCIAAALAASKILRKLAQESGEDDSEEATEMLELANHYEKQAI
GVFSECHSWDAQRAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQA
LLTQIWCGELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDIQRQAERTQ
QKLLKPLNCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMIDFQTSP
SWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRKAKMYIKDLWNILDVLS
IVLFIAGLICRLQASDTVFYIGKVILCIDFIIFCLRLMAIFSISRTLGPK
IIIVRRMMLDLFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYE
PYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTPVFPEWL
TIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDNTDTIWKFQRYELIKEY
HSRPALPPPFILLSHLILFIRGVFLRDLPQRHKNFRQELEQTEEEELLSW
EAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSELLEREQEMVDEEAP
HMFARQLQYPDSTVRRFPVPEEKVSWEVNFSPYQPPVYNQQALDKHRNPG
GRTGIRGKGALNTLGPNHILHPIFTRWRDAEHKVLEFLAVWEDAEKRWAL
LGGPAQPDEPLAQVLERILGKKLNEKTKTLLKAGEEVYKGYVDDSRNTDN
AWVETSIITLHCDKNTPLMADLNHMVESSLSSHQPLQWREVSSDACRCSY
QREALRQIAHHHNTYF
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6drj Chain D Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6drj Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		E857 Q860 N883
Binding residue
(residue number reindexed from 1)		E718 Q721 N744
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0072570 ADP-D-ribose binding
GO:0072571 mono-ADP-D-ribose binding
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019722 calcium-mediated signaling
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6drj, PDBe:6drj, PDBj:6drj
PDBsum6drj
PubMed30250252
UniProtA0A0R4IMY7|TRPM2_DANRE Transient receptor potential cation channel subfamily M member 2 (Gene Name=trpm2)

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