Structure of PDB 6cjt Chain D Binding Site BS02

Receptor Information
>6cjt Chain D (length=396) Species: 869211 (Spirochaeta thermophila DSM 6578) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIP
LDLAFESRRLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLI
SVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPA
GTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIG
NIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWET
RRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILH
LEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFF
GEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ
Ligand information
Ligand IDPCG
InChIInChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChIKeyZOOGRGPOEVQQDX-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C4C(O3)COP(=O)(O4)O)O)N=C(NC2=O)N
ACDLabs 10.04O=C4NC(=Nc1c4ncn1C3OC2COP(=O)(OC2C3O)O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@H]4C(O3)CO[P@](=O)(O4)O)O)N=C(NC2=O)N
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
FormulaC10 H12 N5 O7 P
NameCYCLIC GUANOSINE MONOPHOSPHATE
ChEMBLCHEMBL395336
DrugBankDB02315
ZINCZINC000004095501
PDB chain6cjt Chain D Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cjt Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Resolution3.46 Å
Binding residue
(original residue number in PDB)		Y357 G367 E368 T378
Binding residue
(residue number reindexed from 1)		Y341 G351 E352 T362
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cjt, PDBe:6cjt, PDBj:6cjt
PDBsum6cjt
PubMed30028291
UniProtG0GA88

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