Structure of PDB 6bfz Chain D Binding Site BS02

Receptor Information
>6bfz Chain D (length=438) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQMGRGSMSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGAST
GSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKI
MIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGK
YSMPVPMMNIINGGEHDNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLA
KVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLA
MDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLD
ESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFN
QIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKT
GSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6bfz Chain D Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6bfz Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens.
Resolution2.21 Å
Binding residue
(original residue number in PDB)		D245 E289 D316
Binding residue
(residue number reindexed from 1)		D252 E296 D323
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S41 H158 E167 E208 D245 E289 D316 K341 H369 K392
Catalytic site (residue number reindexed from 1) S49 H166 E174 E215 D252 E296 D323 K348 H376 K399
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0009986 cell surface
GO:0016020 membrane
GO:1990061 bacterial degradosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bfz, PDBe:6bfz, PDBj:6bfz
PDBsum6bfz
PubMed30714720
UniProtP0A6P9|ENO_ECOLI Enolase (Gene Name=eno)

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