Structure of PDB 6a4b Chain D Binding Site BS02

Receptor Information
>6a4b Chain D (length=215) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDLVLPRVL
DKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGFLSR
QEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGLDRA
HSHRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAWAD
EQARSWAHIEPMYVP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6a4b Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6a4b Structural insights into the duplex DNA processing of TREX2
Resolution2.7 Å
Binding residue
(original residue number in PDB)
D14 D123
Binding residue
(residue number reindexed from 1)
D10 D116
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6a4b, PDBe:6a4b, PDBj:6a4b
PDBsum6a4b
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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