Structure of PDB 5zy9 Chain D Binding Site BS02

Receptor Information

>5zy9 Chain D (length=400) Species: 67593 (Phytophthora sojae)

MDHRRLGVSEELFFFHSLSPGSGFWLPHGSAIYFKLLKFIREQYRARGYT
EVITPNIFNMELWNISGHAKHYKENMFVFDVEGQEYALKPMNCPAASLMF
DFRQRSYRELPIRYADCGVLHRNELSGALTGLTRVRRFQQDDAHIFCRDD
QIKKEVLDFLSFMKYVYDVFGIEFNLELSTRPEKAMGELEQWERAESQLA
EALDEFVGAGKWVVNPGDGAFYGPKIDIMITDALKRQHQCATVQLDFQLP
IRFNLKYRTDDADNFKRPVIIHRAIYGSLERFVAVLVEHYAGKFPFWLSP
RQVLIVTVGAAFVDYGYEVKDAMFRAGFDVDIDDTGKTLNKKIREGQMAH
YNFILVVGAHEKETRSVNIRTRDNKVTGTKTLEEAIAMFKELEETKAADE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5zy9 Chain D Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zy9 Structural basis for inhibition of translational functions on a tRNA synthetase
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): C93 H144 H272
• Binding residue (residue number reindexed from 1): C93 H144 H272
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.3: threonine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004829 threonine-tRNA ligase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006418 tRNA aminoacylation for protein translation
• GO:0006435 threonyl-tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5zy9, PDBe:5zy9, PDBj:5zy9
• PDBsum: 5zy9
• UniProt: G3FIN0